Assessing for Trauma and ACEs in Behavioral Pediatric Healthcare 

The health and well-being of Americans are facing a dangerous decline. This decline includes the emotional, economic and developmental safety of our youth and the future of America. In order to secure health outcomes for the American public, creating well-educated and healthy adult populations who can be active health participants in the global economy, in spite of the viral pandemic, corona-19, COVID-19, is paramount. In 2013 and 2014, policy by the American Pediatric Association, The Center for Child Development at Harvard and Mental Health America published public health policies implicating the future of public education, our nation’s workforce and the state of health care at large. In these reports, advocacy for a new era in public health, which presented information for the system-wide recognition of the new science in neuroscience, molecular biology, genomics, developmental psychology, epidemiology and sociology documenting the insights into human development, adverse childhood experiences, stress and chronic illness be taken to build strong foundational programs in healthcare. Their arguments initiated the conclusive dialogue for all fields in the understanding of the role of toxic stress & trauma in childhood, as antecedents to declining health and chronic illness. The following will represent an investigative response to and in-conjunction with the public health summaries of The American Academy of Pediatrics (2013) & Mental Health America (2016) through a systematic review of the literature on assessing for ACEs in primary and behavioral pediatric care. 

Defining Adverse Childhood Experiences

There is well established evidence that childhood adversities such as abuse or neglect can result in lifelong negative health outcomes. This body of evidence has resulted in growing awareness of the concept entitled toxic stress, which is described as the chronic and frequent activation of the stress response from exposure to serious childhood adversity (Dvir, Ford, Hill, & Frazier, 2014). Negative health outcomes for children who experience toxic stress reflect the physiological, epigenetic and cognitive consequences that the brain and body pay for adapting to stressful and traumatic experiences. The Adverse Childhood Experience (ACE) study (Felitti et al, 1988), found a bidirectional relationship between ACEs scores and many leading causes of death in adults including cardiovascular disease. It also found increased on-set for the development of psychiatric disorders like PTSD, depression, psychosis and schizophrenia (Slavich et al.,2019; Felitti et al.,1988). The relationship between ACEs and toxic stress is a major contributor to the foundations of health policy in today’s healthcare initiatives.

The term “ACEs” is an acronym for Adverse Childhood Experiences. It was first developed in

a groundbreaking study conducted in 1995 by the Centers for Disease Control and Kaiser

Permanent. It was also the subject of formal research exploration by Fetilli in 1988. In the

“ACEs” study, three specific kinds of adversity children were exposed to were – abuse, neglect,

physical/ sexual violence and household dysfunction.

The key findings from the study published since are (1) ACEs are quite common, more than two- thirds of the population report experiencing one ACE, and nearly a quarter have experienced three or more. (2) There is a powerful, persistence correlation between the number of ACEs experienced and the chance of poor outcomes later in life, including dramatically increased risk of heart disease, diabetes, obesity, depression, substance abuse, smoking, poor academic achievement, time out of work, and early death (Harvard Center for the Developing Child, 2020).

Population: Where does the Literature Intersect? 

All children face and experience moments of diversity and adversity. While trauma may be very significant the impact of a traumatic event can be buffered by pro-social support figures. However, when the trauma is prolonged and severe enough, the impact can be deeply distressing and cause chronic injury. Among these are children faced with contributing social determinants of health including those who are sent to social services, those living in low socioeconomic conditions and those in chronically violent/ hostile environments. 


Environmental factors like violence, low socioeconomic conditions and lack of

nutritional resources impact the development of stress along the spectrum.

Mental Health & Chronic Illness 

Chronic Illness is defined as the consequences of low grade inflammation across the life spectrum including physical and psychological ailments. It has been reported that those with higher scores of ACEs, experience low to mild long-term chronic health conditions like depression, suicidality, autoimmune dysregulation, asthma, headaches and neurological deficits like cognitive focus and functioning. 

High Levels of Chronic Inflammation 

Elevated levels of inflammation are exhibited through biomarkers of proinflammatory cytokines from the myeloid region. These biomarkers can be found in many chronic

illnesses like cancer, autoimmune disorders and neurological disorders are labeled as CRP, TNF-a, IL-10, IL-6, IL-1. 

ACEs and Inflammation 

Research on the science behind the psychoneuroendocrine system is expansive as it relates to  toxic stress aiding in the development of long-term chronic disease, which may be mediated through the secretion of long-lasting inflammation. Understanding inflammation as a major causal factor to the association between ACEs and chronic disease is important when modifying programmatic content, developing novel psychopharmacological therapies (anti-inflammatory), assessing for ACEs and teaching advanced mental health therapies to qualified practitioners. 

In studies documenting the understanding of inflammation in relation with ACEs, research found

higher rates of pro-inflammatory biomarkers in individuals who self-reported adverse childhood experiences, including a meta-analysis of women who had undergone childhood sexual abuse (CSA) displaying higher levels of Il-6, CRP and IL-10.Supporting these connections in animal studies, are rats who underwent a postnatal maternal separation protocol during infancy

and showcased increased levels of IL-6 later in the lifespan (Gangley & Brenhouse, 2015; Hennessy et al., 2010). In epidemiological follow-up studies in New Zealand, researchers discovered by following 1,000 participants from birth to 32 years, who showcased episodes of critical maltreatment including abuse, social isolation and economic hardship developing twice as likely consequences to suffer from chronic inflammation in later life (Halaris, 2017). Therefore, the connection between high-inflammation and ACEs is consistent throughout the research literature. Yet, determining the exact biological and physiological role inflammation plays as a specific variable in the association between ACEs and chronic disease is still not quite understood. With scientific literature in neuroscience that can detail the neurological impact of ACEs on the endocrine system, there is little research identifying how activating the long-term stress response can produce negative health risk outcomes and morbidity. However, health risk behaviors are directly mediated by their relationship with childhood abuse (Chartier, Walker, Naimark, 2009). Often, individuals cope with the effects of adult symptoms of childhood trauma by engaging in unhealthy, avoidant behaviors, such as overeating, smoking, and excessive alcohol use (Su et al, 2015). Although, the relationship between health risks and ACEs is highly known, there is little information is given on the development of inflammation & ACEs as pathways to increased risk for negative health outcomes including physical inactivity, poor sleep, poor emotional regulation, dietary decision-making, obesity and race.

kids making noise and disturbing mom working at home
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Long-term Chronic Inflammation May Have Three Intervention Points 

Further research and development into the science of toxic stress is still being administered as it relates to understanding how ACEs and toxic stress create long-term negative outcomes for  disease. The immune system is an intricate part of the factors developed in brain behavior and the prevention of infection. The innate immune system serves as an initial defense system to combat an infection (Slavich, 2019) and has traditionally been a source of fighting against foreign bacteria, antibodies and pathogens which protects us from disease. However, due to its complex nature, when the immune system feels threatened, the response to protect against harm is rapid. When the body senses a biological threat, but the innate immune system is insufficient in fighting off the perceived intrusion, the proliferation of pro-inflammatory myeloid cells will be produced and have a wide-ranging effect on mood, cognition, and behavior (Slavich 2019, Irwin 2008). These cells are exceptional for they have the ability to remember the homeostatic event or experience. There in, resulting in the proliferation of low grade cytogenetic attacks across the lifespan. For instance, IL-1 and IL-6 receptors in the brain interrupt the communication between nerve cells and the hippocampus, inhibiting neural pathways to develop in memory and sensitivity to stress (Barrientos et al, 2009). The findings in these studies suggest that stress-induced activation of inflammatory processes can result in increased inflammatory cytokines such as IL-I, which impairs the brain’s ability to invoke neuroplasticity and neurogenesis.When inflammation in the brain is chronic, the impact on neurogenesis and neuronal activity is highly demonstrative. Inflammation does not only have an impact via the effects of proliferation, survival and cell death, but can affect the integration of new neurons into pre-existing neural networks and the cellular properties of the new cells that survive (Slavich, 2019; Haroon,Raison, & Miller, 2011). Therefore with the development of ACEs, neuroplasticity is not a regenerative intervention, causing a cyclical loop between immune activation & behavior. Interventions can be implemented through supporting and co-regulating the child’s immune system with stress reduction techniques and other biotechnological procedures in the field of pediatrics and gut health. However, without social and behavioral implementation, for the meditating variables like behavioral pathways, increased risk for disease will still occur due to confounding factors. With that being said, a biological intervention for a socioecological problem is a binary approach to a multisystems matrix for disease control. 

What’s the Best Solution? 

If the body is a structured organism working within the context of its environment in relation to susceptibility of disease. Then, stabilizing the child’s environment is a second-test protocol that may serve as a measure to decrease stress activation at the chronic or severe level. With that, integrated behavioral health and pediatric care models must work to help establish basic assessment strategies to increase the stability of the child’s home life. Understanding the specific population barriers for accepting treatment of integrated care models for psychotherapy and stress reduction is a key initiative in disrupting the behavioral pathways prolonging chronically inflamed children and adolescents. Using a change and intervention model, it is important to implement family-based interventions at early stages of child development including the prenatal and perinatal stage. Beyond assessing ACEs in pediatric healthcare, increasing awareness of the science and brian damage of adverse childhood effects for mothers and fathers having children is a best-case intervention for establishing lines of family and marriage counseling and the integration of childhood pediatrics. Utilizing different change models will be essential in helping to combat the effects of ACEs which could include the transtheoretical model of change at the micro-level within the counseling room and then outwards models to help implement education strategies to mothers regarding the devastating impact that ACEs has on the family unit and the long-term health outcomes of the individual. Implementing social norms theory could be another solution to help mitigate and motivate individuals to integrate and screen for ACEs in childhood pediatrics while implementing therapeutic interventions to help stabilize the immune system. 


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